Differentiation of T Regulatory Cells by Immature Dendritic Cells
نویسندگان
چکیده
منابع مشابه
Differentiation of T Regulatory Cells by Immature Dendritic Cells
The induction of antigen-specific tolerance is critical for the prevention of autoimmunity and maintenance of immune homeostasis. The immune system's ability to distinguish between self and non-self and between innocuous and harmful foreign antigens is controlled by mechanisms of central and peripheral tolerance. Central tolerance is a well established mechanism that involves deletion of self-r...
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Dendritic cells (DCs) are specialized APCs with an important role in the initiation and regulation of immune responses. Immature DCs (iDCs) reportedly mediate tolerance in the absence of maturation/inflammatory stimuli, presumably by the induction of regulatory T cells. In this study, we show for the first time that repetitive iDC injections trigger the expansion of a novel regulatory populatio...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2001
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.193.2.f5